Recent Publications
2024
Targeted cohesin loading characterizes the entry and exit sites of loop extrusion trajectories Han, R.#, Huang, Y., Vaandrager, I., Allahyar, A., Magnitov, M., Verstegen, M., de Wit, E., Krijger, P.H.L., de Laat, W. Manuscript in revision
2022
Building regulatory landscapes reveals that an enhancer can recruit cohesin to create contactdomains, engage CTCF sites and activate distant genes Rinzema, N.J., Sofiadis, K., Tjalsma, S.J.D., Verstegen, M.J.A.M., Oz, Y., Valdes-Quezada, C., Felder, A.K., Filipovska, T., van der Elst, S., de Andrade dos Ramos, Z., Han, R., Krijger, P.H.L., de Laat, W.* Nature Structural & Molecular Biology, 2022, 29(6): 563-574 DOI: 10.1038/s41594-022-00785-9
2021
A comprehensive enhancer screen identifies TRAM2 as a key and novel mediator of YAP oncogenesis Li, L., Ugalde, A.P., Scheele, C.L.G.J., Dieter, S.M., Nagel, R., Ma, J., Pataskar, A., Korkmaz, G., Elkon, R., Chien, M.P., You, L., Su, P.R., Bleijerveld, O.B., Altelaar, M., Momchev, L., Manber, Z., Han, R., van Breugel, P.C., Lopes, R., Ten Dijke, P., van Rheenen, J., Agami, R.* Genome Biology, 2021, 22(1): 1-28 DOI: 10.1186/s13059-021-02373-5
2020
Transcription Dynamics Regulate Poly(A) Tails and Expression of the RNA Degradation Machinery to Balance mRNA Levels Slobodin, B., Bahat, A., Sehrawat, U., Becker-Herman, S., Zuckerman, B., Weiss, A.N., Han, R., Elkon, R., Agami, R., Ulitsky, I., Shachar, I., Dikstein, R.* Molecular Cell, 2020, 78(3): 434-444 DOI: 10.1016/j.molcel.2020.03.007
2019
SLC1A3 contributes to L-asparaginase resistance in solid tumors Sun, J., Nagel, R., Zaal, E.A., Ugalde, A.P., Han, R., Proost, N., Song, J.Y., Pataskar, A., Burylo, A., Fu, H., Poelarends, G.J., van de Ven, M., van Tellingen, O., Berkers, C.R., Agami, R.* The EMBO Journal, 2019, 38(21): e102147 DOI: 10.15252/embj.2019102147
2018
Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescence Han, R.#, Li, L.#, Ugalde, A.P., Tal, A., Manber, Z., Barbera, E.P., Della Chiara, V., Elkon, R., Agami, R.* Genome Biology, 2018, 19: 118 DOI: 10.1186/s13059-018-1495-0
LncRNA-OIS1 regulates DPP4 activation to modulate senescence induced by RAS Li, L., van Breugel, P.C., Loayza-Puch, F., Ugalde, A.P., Korkmaz, G., Messika-Gold, N., Han, R., Lopes, R., Barbera, E.P., Teunissen, H., de Wit, E., Soares, R.J., Nielsen, B.S., Holmstrøm, K., Martínez-Herrera, D.J., Huarte, M., Louloupi, A., Drost, J., Elkon, R., Agami, R.* Nucleic Acids Research, 2018, 46(6): 3214-3227 DOI: 10.1093/nar/gky087
2017
Transcription impacts the efficiency of mRNA translation via co-transcriptional N6-adenosine methylation Slobodin, B.#, Han, R.#, Calderone, V., Oude Vrielink, J.A.F., Loayza-Puch, F., Elkon, R., Agami, R.* Cell, 2017, 169(2): 326-337 DOI: 10.1016/j.cell.2017.03.031
The Methylated way to translation Han, R., Slobodin, B., Agami, R. Oncotarget, 2017, 8(55): 93313-93314 DOI: 10.18632/oncotarget.21871
2016
Functional genetic screens for enhancer elements in the human genome using CRISPR-Cas9 Korkmaz, G.#, Lopes, R.#, Ugalde, A.P., Han, R., Myacheva, K., Zwart, W., Elkon, R., Agami, R.* Nature Biotechnology, 2016, 34(2): 192-198 DOI: 10.1038/nbt.3450
2012
Adenosine triphosphate‐binding cassette transporter genes up‐regulation in untreated hepatocellular carcinoma is mediated by cellular microRNAs Borel, F., Han, R., Visser, A., Petry, H., van Deventer, S.J.H., Jansen, P.L.M., Konstantinova, P., with collaboration of the Réseau Centre de Ressources Biologiques Foie (French Liver Biobanks Network), France Hepatology, 2012, 55(3): 821-832 DOI: 10.1002/hep.24682
实验室发表文章列表持续更新中… / Publication list is continuously updated…
* 通讯作者 / Corresponding author
如需获取全文PDF或有合作意向，请联系韩老师：r.han@nju.edu.cn
For full-text PDFs or collaboration inquiries, please contact Dr. Han: r.han@nju.edu.cn
Institute of Modern Biology,Nanjing University